Dog trazodone dose calculator

More recently, eight studies were performed with depressed or dysthymic patients, and these studies focused on the effects of trazodone in treating medication-induced or depression-associated insomnia. 41, 42, 44 – 48, 50 In an open-label, six-week RCT, the effective dose of trazodone was evaluated in 75 subjects, with a 50mg/d …

Dog trazodone dose calculator. 120 – 240 mg. 80 – 160 mg. 50+ lbs. 150 – 300 mg. 100 – 200 mg. Key Takeaways: Start low, go slow: Always begin at the lower end of the dosage range, especially if your dog has never taken Gabapentin before. One size does not fit all: Adjust the dosage based on your dog’s reaction and always under veterinary supervision.

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Introduction. In 2016, an estimated 6.1 million US children (9.4%) had ever received an attention deficit hyperactivity disorder (ADHD) diagnosis, with 62% receiving medication treatment, 46.7% receiving behavioral treatment, and 23% receiving neither. 1 Primary care providers in pediatrics and family practice prescribe most of the …Not every dog has the same reaction to trazodone, but some dogs have suffered from seizures after taking trazodone. The dosage of Trazodone that your dog should receive depends on their weight. A general rule of thumb is that you add up the trazodone dose for an adult human and divide by ten to get the right amount for a dog …The suggested Trazodone dosage range for your dog is , taken by mouth. While Trazodone is not FDA-approved for use in dogs, it is commonly prescribed for off-label use. Share the results of your dog’s dosage recommendation with your veterinarian and discuss whether Trazodone is a good choice for them.Do not use trazodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection ...Dose may increase by 50 mg per day every 3–4 days. The maximum dose is 400 mg per day in divided daily doses. A person should take tablets or pills whole or cut in half.Objective: This retrospective study examines whether long-term use of trazodone, an SWS enhancer, is associated with delayed cognitive decline. Methods: We identified 25 regular trazodone users (mean age 75.4±7.5; 9 women, 16 men) who carried a diagnosis of Alzheimer's dementia, mild cognitive impairment, or normal cognition, and 25 propensity ...India's administered roughly 15% of the world's Covid-19 doses. Yet, it has some distance to cover. India has now administered over a billion doses of Covid-19 vaccines, only the s...

The cost of owning a dog throughout its lifetime can put pet owners out of thousands of dollars. By clicking "TRY IT", I agree to receive newsletters and promotions from Money and ...Oct 25, 2007 · The effect of short-term administration of ritonavir (200 mg twice daily, 4 doses) on the pharmacokinetics of a single dose of trazodone (50 mg) has been studied in 10 healthy subjects. The C max of trazodone increased by 34%, the AUC increased 2.4-fold, the half-life increased by 2.2-fold, and the clearance decreased by 52%. Adverse effects ... Guidelines. Gabapentin dosage in dogs varies depending on the specific condition being treated. Anticonvulsant: Every eight hours, give your dog 4.5 to 9 mg per pound of weight. Neuropathy: Initially, administer 2.3 to 6.8 mg per pound every 12 hours. It can be increased later.Indices Commodities Currencies StocksA 2018 meta-analysis examining the use of trazodone for insomnia included seven RCTs with 429 adults (mean age = 46.1 years; range = 38.2 to 81 years; 58.2% female).The cost of owning a dog throughout its lifetime can put pet owners out of thousands of dollars. By clicking "TRY IT", I agree to receive newsletters and promotions from Money and ...The FDA reports that peak plasma levels of trazodone occur around one hour after dosing when a person takes the medication on an empty stomach and around two hours when the person takes the medication with food. The plasma elimination half-life of trazodone differs from older people (13.6 hours) to younger people (6 hours) in the …Your vet will give you specific dosing instructions, since trazodone may last between six and 12 hours, depending on your dog. They’ll likely start you on the lowest recommended dose, Greenstein …

Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults. 2.1 Dose Selection - An initial dose of 150 mg/day in divided doses is suggested. The dosage should be initiated at a low-dose and increased gradually, noting the clinical response and any ...For oral dosage form (tablets):. Adults—At first, 150 milligrams (mg) per day, given in divided doses. Your doctor may adjust your dose as needed. However ...Jan 31, 2024 · Trazodone is a medication that has gained popularity in veterinary medicine for its sedative and anxiolytic properties. Originally developed as an antidepressant for humans, it is now commonly prescribed to dogs for a variety of behavioral issues. It is important for dog owners and veterinarians alike to understand the uses, correct dosage, and potential side effects of trazodone to ensure the ... Trazodone overdose can occur when a person takes too much trazodone at one time. Signs and symptoms of an overdose may include excessive drowsiness, low blood pressure, fainting, or an irregular heartbeat. When trazodone is taken with other medications that affect serotonin levels, a severe and sometimes fatal condition called …Your vet will give you specific dosing instructions, since trazodone may last between six and 12 hours, depending on your dog. They’ll likely start you on the lowest recommended dose, Greenstein …

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RDTCF: Get the latest Rapid Dose Therapeutics stock price and detailed information including RDTCF news, historical charts and realtime prices. Indices Commodities Currencies Stock...Trazodone monotherapy versus placebo (4 RCTs, 209 men): trazodone increased the likelihood of a positive treatment response compared with placebo, but the increase was not statistically significant. The pooled RBI was 1.6 (95% CI: 0.8, 3.3). The results for treatment response according to type of ED and trazodone dose were also reported in the ...A safe dosage of trazodone for dogs is generally 2-3.5 mg/lb of body weight, George says. The specific amount prescribed by your veterinarian will vary, depending on your dog’s breed,...Side Effects. See also the Warning section. Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the ...The FDA reports that peak plasma levels of trazodone occur around one hour after dosing when a person takes the medication on an empty stomach and around two hours when the person takes the medication with food. The plasma elimination half-life of trazodone differs from older people (13.6 hours) to younger people (6 hours) in the …

Trazodone can be used long-term (generally given twice a day with or without food) or on an as-needed basis. It can take up to two weeks to achieve maximum anxiety relief when trazodone is used long-term. Side Effects. When trazodone use has been studied in dogs, 80 percent of dogs using trazodone experienced no negative side effects.Trazodone hydrochloride tablets, USP are indicated for the treatment of major depressive disorder (MDD) in adults. 2.1 Dose Selection - An initial dose of 150 mg/day in divided doses is suggested. The dosage should be initiated at a low-dose and increased gradually, noting the clinical response and any ...Days of supply is a term used to quantify the number of days a given quantity will last under certain conditions. Calculate the number of doses being consumed on any given day. For...The dose of 50 to 200 mg of trazodone has been shown to reduce nightmare episodes of nightmares as well as improve sleep habits in studies involving PTSD patients. According to the American Academy of Sleep Medicine (AASM), trazodone is suggested to treat nightmares associated with PTSD. [5] However, various studies …It’s essential to speak with a veterinarian, and always follow a doctor’s directions on dosage. Generic trazodone comes in 50 milligram, 100 milligram, 150 milligram, and 300-milligram tablets. One study showed the mean dose was 15 milligrams per kilogram of weight per day. Dogs may need to work up to the best dose for them.A vet may prescribe trazodone for dogs who struggle with phobias, situational anxiety, or other behavioral issues. While trazadone may make these dogs less anxious, giving a new medication can be a bit anxiety-inducing for dog parents. To help them feel prepared, integrative veterinarian Dr. Julie Buzby explains the uses, dosage, …The typical dosage range for Trazodone in dogs is 2 to 7 mg per pound of body weight, administered every 8 to 24 hours. For example, a 30-pound dog might receive a dose of 60 to 210 mg, depending on the severity of the condition.How to take it. Your doctor may advise you to take your dose of trazodone once a day. If you have a larger dose, your doctor may suggest that you split it and take it twice a day. If your dose is 300mg a day or less, your doctor will probably tell you to take it as a single dose at bedtime. As trazodone can make you feel sleepy, taking it at ...May 1, 2024 · Trazodone may cause dry mouth. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth ... Vets have the expertise to provide personalized dosage recommendations based on your dog’s specific needs and medical history. Weight-based dosage guidelines for Trazodone are typically used as a starting point. Dogs weighing between X and Y pounds are typically given Z amount of Trazodone.

The cost of owning a dog throughout its lifetime can put pet owners out of thousands of dollars. By clicking "TRY IT", I agree to receive newsletters and promotions from Money and ...

Find everything you need to know about trazodone (Desyrel), including what it's used for, warnings, reviews, side effects, and interactions. Learn more about trazodone (Desyrel) at EverydayHealth.com.Trazodone selectively blocks serotonin reuptake, which enhances serotonin’s effects. 4 It is an antagonist of 5-HT 2A, H1-histaminic, and α1-adrenergic receptors at low to moderate doses, resulting in various levels of sedation. 3–6 It can have hypotensive effects. 4 At higher doses, trazodone acts as a serotonin agonist, and serotonin ...Not every dog has the same reaction to trazodone, but some dogs have suffered from seizures after taking trazodone. The dosage of Trazodone that your dog should receive depends on their weight. A general rule of thumb is that you add up the trazodone dose for an adult human and divide by ten to get the right amount for a dog …Buy Trazodone Tablets Online - Free Worldwide Shipping Trazodone is an oral state of mind elevator considered depression, anxiety (when it's a sign of misery), in addition to for agoraphobia, panic strikes and boosted aggressiveness. 16030 Barber Creek Ave Kent City, MI 34675. Call Us Today (616) 675-4675.For trazodone hydrochloride. Withdrawal effects may occur within 5 days of stopping treatment with antidepressant drugs; they are usually mild and self-limiting, but in some cases may be severe. The risk of withdrawal symptoms is increased if the antidepressant is stopped suddenly after regular administration for 8 weeks or more.Sep 1, 2023 · It’s essential to speak with a veterinarian, and always follow a doctor’s directions on dosage. Generic trazodone comes in 50 milligram, 100 milligram, 150 milligram, and 300-milligram tablets. One study showed the mean dose was 15 milligrams per kilogram of weight per day. Dogs may need to work up to the best dose for them. The starting dose for trazodone in dogs is 2.5 mg per kilogram of body weight (1 kg = 2.2 lbs). To calculate the starting dose (in mg) divide the dog’s weight (in lbs) by 2.2. Then, multiply that number by 2.5. Example: A 25 lb dog weighs 11.36 kg. The starting dose is 11.36 kg x 2.5 = 28.4 mg.

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The suggested Trazodone dosage range for your dog is , taken by mouth. While Trazodone is not FDA-approved for use in dogs, it is commonly prescribed for off-label …The effect of short-term administration of ritonavir (200 mg twice daily, 4 doses) on the pharmacokinetics of a single dose of trazodone (50 mg) has been studied in 10 healthy subjects. The C max of trazodone increased by 34%, the AUC increased 2.4-fold, the half-life increased by 2.2-fold, and the clearance decreased by 52%. Adverse effects ...Nov 7, 2022 · The initial starting dose usually is 150 mg per day, which is increased by 50 mg/day every 3-7 days. Trazodone regular tablets are given in one or more daily doses, sometimes with the largest dose at night. The dose of extended-release tablets is 150 mg at bedtime initially which is increased by 75 mg/day every 3 days. The effect of short-term administration of ritonavir (200 mg twice daily, 4 doses) on the pharmacokinetics of a single dose of trazodone (50 mg) has been studied in 10 healthy subjects. The C max of trazodone increased by 34%, the AUC increased 2.4-fold, the half-life increased by 2.2-fold, and the clearance decreased by 52%. Adverse effects ...For Insomnia "I started trazodone at 150mg for insomnia April 22. The side effects I experienced were dry mouth, mild headache, dizziness, nervousness and shakiness. Told my primary doctor about it so he lowered my dose to 100mg after three weeks. I’ve been on the new dose since May 15 and I still feel the same side effects.As seniors enter the golden years of their lives, they often seek companionship and a sense of purpose. Small dogs can be the perfect addition to their lives, providing love, affec...Apr 4, 2023 · Dry mouth, headache, constipation, diarrhea, and sexual dysfunction. Trazodone may cause a discontinuation syndrome if abruptly stopped, symptoms include anxiety, agitation, and sleep disturbances. When the time comes to withdraw trazodone, the dosage should be tapered off slowly under a doctor's advice. Jan 4, 2017 · Trazodone can be used long-term (generally given twice a day with or without food) or on an as-needed basis. It can take up to two weeks to achieve maximum anxiety relief when trazodone is used long-term. Side Effects. When trazodone use has been studied in dogs, 80 percent of dogs using trazodone experienced no negative side effects. RDTCF: Get the latest Rapid Dose Therapeutics stock price and detailed information including RDTCF news, historical charts and realtime prices. Indices Commodities Currencies Stock...Immediate release: Initial: 50 mg twice daily; may increase in increments of 50 mg/day every 3 to 7 days to a target dose of 75 to 150 mg twice daily. Thereafter may further increase by 50 to 100 mg/day every 2 to 4 weeks based on response and tolerability; usual dosage range 200 to 400 mg/day; maximum 600 mg/day.Trazodone is a short-acting drug. Side effects in dogs are not well documented but are generally mild if present. Possible side effects include dilated pupils, sedation, lethargy, vomiting or gagging, colitis (inflammation of the colon), ataxia (loss of muscle control), priapism (persistent and painful erection of the penis), arrhythmias ...The initial dose of trazodone should be small and then gradually increased depending on how well your dog tolerates it. The following table gives the initial dosage for dogs which may be slowly increased after 3 to 5 days towards the target dose depending on how well your dog tolerates it. ….

Aug 10, 2023 · Initial dose: 150 mg orally per day in divided doses; this may be increased by 50 mg orally per day every 3 to 4 days. Maximum dose: Inpatients: 600 mg/day. Outpatients: 400 mg/day. Comments: Patients should be screened for a personal/family history of bipolar disorder, mania, or hypomania prior to initiating treatment. Never give your pet two doses at once or give extra doses. Are there any potential side effects? Trazodone is a short-acting drug. Side effects in dogs are not ... Side Effects. See also the Warning section. Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the ... Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. phenytoin. trazodone increases levels of phenytoin by unspecified interaction mechanism.Dose Selection . An initial dose of 150 mg/day in divided doses is suggested. The dosage should be initiated at a low-dose and increased gradually, noting the clinical response and any evidence of intolerance. Occurrence of drowsiness may require the administration of a major portion of the daily dose at bedtime or a reduction of dosage.Official answer. by Drugs.com. The U.S. Food and Drug Administration (FDA) does not recognize trazodone as a controlled substance because studies have not shown that people who take trazodone are likely to start abusing the drug. A controlled substance is an illegal or prescription drug deemed addictive or inclined to result in drug abuse and ...Desyrel (Trazodone Hydrochloride) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. ... The initial adult dose of trazodone is 150 mg/day in divided doses. The dose may be increased by 50 mg/day every three to four days.Some have not clarified whether they consider passengers who took two different Covid-19 vaccines to be fully vaccinated. As more countries open up their borders to vaccinated trav...Another common side effect of Trazodone in dogs is colitis. Or the inflammation of the colon. Moreover, this can result to even more side effects. You see, colitis causes reduced water absorption in the GI tract. Then, that lowers the ability to store feces in the colon. With that, your dog will also experience diarrhea.Niche uses for Trazodone ——————— • Anti-akathisia agent. For this reason alone Trazodone is far from useless. • An excellent adjunctive medication to all classes of psych medication, from SSRIs to mood-stabilizers. • Preliminary research pointing torwards a reduction of withdrawal symptoms from different drugs of abuse. Dog trazodone dose calculator, Trazodone Dosage and Administration. Adult . ≥18yrs: initially 150mg/day in divided doses with food. May increase by 50mg/day at 3–4 day intervals; max 400mg/day (outpatients) or 600mg/day ..., The targeted intervention was a minimum dose of 25 mg of trazodone daily, for at least 1 week, to observe the chronic effects of this drug and not the effects obtained after a single dose. Consequently, we excluded studies that only tested the acute effects of trazodone by using it in a one-time-only fashion., This summer, you should be planning trips that will get you outside and immersed in nature — and your doctor will thank you. This summer, you should be planning trips that will get..., Bringing a new puppy into your home is an exciting and joyful experience. As a responsible pet owner, it is important to ensure that your furry friend grows up healthy and strong. ..., Trazodone for dogs dosage chart (by weight) Dosage: Per kg of weight: Per lbs of weight: Minimum: 3.74 mg: 1.7 mg: Maximum: 43 mg: 20 mg: Trazodone for dogs: 17 side effects. First of all, Trazodone is an FDA-approved medication for humans only. That’s why there are no veterinary formulations of the medication yet., Here’s a simple yet insightful chart to guide you through the dosage process, keeping in mind that Trazodone comes in 50mg tablets: Dog’s Weight (lbs) Starting Dose (mg/kg) Starting Dose (50mg Tablet Fraction) Optimal Dose Range (mg/kg) Optimal Dose Range (50mg Tablet Fraction) 5 – 10. 2. 1/4., However, it may be hard to calculate the timing, so you may need to run a practice test a few days before the stressful event so you can watch your dog’s reaction and optimize the amount of time necessary for the drug to take effect. Trazodone Dosage For Dogs. The safe dose of trazodone depends on your dog’s weight and health condition ..., Trazodone. 3–8 mg/kg, prn to tid. Anticonvulsants. Carbamazepine. 4–8 mg/kg, bid-tid. 2–6 mg/kg, one to two times/day. Gabapentin. 5–30 mg/kg, bid-tid. 3–10 mg/kg, bid-tid . Levetiracetam. 20 mg/kg, tid . 10–20 mg/kg, tid . Phenobarbital d. 2–5 mg/kg, bid (to 10 mg/kg, prn for sedation) 1–3 mg/kg, bid. Potassium bromide d. 10 ..., Oct 7, 2022 · Dosage. Side Effects. Warnings and Interactions. Trazodone is an antidepressant in the serotonin modulators class of drugs. It is used to treat depression and works by increasing the action of serotonin in your brain. In addition to being used for managing depression, it can be used to treat insomnia and anxiety. , Jun 7, 2021 · The targeted intervention was a minimum dose of 25 mg of trazodone daily, for at least 1 week, to observe the chronic effects of this drug and not the effects obtained after a single dose. Consequently, we excluded studies that only tested the acute effects of trazodone by using it in a one-time-only fashion. , Trazodone doses between 25 and 150 mg do not achieve antidepressant activity but have hypnotic activity through antagonism of 5-HT 2a, H 1, and α1 receptors.Estimates of brain receptor occupancy based on a pharmacokinetic model support the multimodal activity of trazodone, which may contribute to the rapid onset of …, The drug dosage range will be automatically calculated. Search and filter the formulary by Drug name or Category. Print your results with the print button . Reset the calculator …, Serious side effects of Trazodone. Along with its needed effects, trazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking trazodone: More common. Blurred vision ..., Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. phenytoin. trazodone increases levels of phenytoin by unspecified interaction mechanism., Objective: This retrospective study examines whether long-term use of trazodone, an SWS enhancer, is associated with delayed cognitive decline. Methods: We identified 25 regular trazodone users (mean age 75.4±7.5; 9 women, 16 men) who carried a diagnosis of Alzheimer's dementia, mild cognitive impairment, or normal cognition, and 25 propensity ..., Side Effects. See also the Warning section. Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the ..., You already know it’s good to keep your CPR chops up to date so you can help a human, but dogs and cats can benefit from CPR too. The guidelines are similar—just do the compression..., Dosage and Administration. According to the appropriate trazodone summary of product characteristics (SPC) [31–33], therapy should begin with an evening administration (starting dose 75–150 mg before bedtime).Subsequently, the dose can be increased every 3 days up to 300 mg/day, to be administered in repeated doses after …, This medication is typically well-tolerated in dogs. In fact, in one study, about 80% of dogs receiving Trazodone did not suffer any negative side effects over the course of being on it for several months to even years. Some potential side effects, while rare, could include: Sedation. Lethargy. Imbalanced walking. Vocalization. …, For depression: For oral dosage form (extended-release tablets): Adults—At first, 150 milligrams (mg) per day as a single dose. Your doctor may adjust your dose as needed. However, the dose is usually not more than 375 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 150 ..., The cost of owning a dog throughout its lifetime can put pet owners out of thousands of dollars. By clicking "TRY IT", I agree to receive newsletters and promotions from Money and ..., Trazodone is a serotonin reuptake inhibitor (SSRI). This is commonly used to treat anxiety and depression or help with storm phobias. Trazodone works in the brain by keeping serotonin in the brain’s synaptic space for a longer time. Serotonin is responsible for your dog feeling good. This will help make your dog happier and stress-free., Side Effects. See also the Warning section. Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/pain, dry mouth, bad taste in the ... , Trazodone has severe interactions with at least 17 other drugs. Trazodone has serious interactions with at least 124 other drugs. Trazodone has moderate interactions with at least 415 other drugs. Trazodone has minor interactions with at least 137 other drugs. This information does not contain all possible interactions or adverse effects., Trazodone. Brand name: Molipaxin. Find out how trazodone treats depression and anxiety and how to take it. About trazodone. Who can and cannot take it. How and when to take it. Side effects. Pregnancy, breastfeeding and fertility. Taking trazodone with other medicines and herbal supplements., Here are the top 5 facts you need to know before attempting to wean your dog off Trazodone: 1. Taper gradually: It is essential to reduce the dose of trazodone gradually instead of suddenly stopping the medication. The withdrawal symptoms can cause rebound anxiety or depression in your pet if it’s done abruptly., Guidelines. Gabapentin dosage in dogs varies depending on the specific condition being treated. Anticonvulsant: Every eight hours, give your dog 4.5 to 9 mg per pound of weight. Neuropathy: Initially, administer 2.3 to 6.8 mg per pound every 12 hours. It can be increased later., Trazodone dosage for dogs. Trazodone is typically supplied in the form of a small white tablet and, less commonly, it might be supplied as a liquid or a capsule. While some canines receive this drug 2-3 times a day on an ongoing basis, many dogs only take it intermittently, i.e. before highly stressful events. ..., Trazodone. 3–8 mg/kg, prn to tid. Anticonvulsants. Carbamazepine. 4–8 mg/kg, bid-tid. 2–6 mg/kg, one to two times/day. Gabapentin. 5–30 mg/kg, bid-tid. 3–10 mg/kg, bid …, Desyrel (Trazodone Hydrochloride) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. ... The initial adult dose of trazodone is 150 mg/day in divided doses. The dose may be increased by 50 mg/day every three to four days., Bull-Dog Sauce News: This is the News-site for the company Bull-Dog Sauce on Markets Insider Indices Commodities Currencies Stocks, Here are the top 5 facts you need to know before attempting to wean your dog off Trazodone: 1. Taper gradually: It is essential to reduce the dose of trazodone gradually instead of suddenly stopping the medication. The withdrawal symptoms can cause rebound anxiety or depression in your pet if it’s done abruptly., Monitor for possible worsening of depression, suicidality, or unusual changes in behavior, especially at the beginning of therapy or during periods of dosage adjustments. (See Worsening of Depression and Suicidality Risk under Cautions.) Sustained therapy may be required; use lowest effective dose and monitor periodically for need for continued ...