New actress in vraylar commercial 2023 name

The US FDA has approved AbbVie's (ABBV) atypical antipsychotic Vraylar (cariprazine) as an adjunct to an antidepressant for major depressive disorder.

New actress in vraylar commercial 2023 name. Winnipeg, Manitoba--(Newsfile Corp. - May 1, 2023) - VRAYLAR (cariprazine) for the treatment of Schizophrenia in adults has received exception medication status on the list of medications in the ...

Who does the Vraylar voice over? Debra Lynn Winger (born May 16, 1955) is an American actress. Lola Falana, Actress: The Liberation of L.B. You can connect with VRAYLAR on Facebook or by phone at 1-877-6VRAYLAR. Who is the singer in the Super Bowl commercial? Bruce Springsteen makes rare commercial appearance in Super Bowl ad to call for unity.

Cariprazine 1.5mg, Oral capsule. Alcohol. · Severity: Major. · Notes for Consumers: Do not drink alcohol while taking this medication. Drinking alcohol while taking this medication can cause serious side effects, such as central nervous system (CNS) depression, and can increase the risk of falling. Call emergency services right away if you ...Vraylar (cariprazine) is an atypical antipsychotic that treats mental health conditions such as bipolar depression and schizophrenia. It interacts with a number of medications. Carbamazepine (Tegretol), phenytoin (Dilantin), and rifampin (Rifadin) interact with Vraylar by lowering its levels in your body. This can make Vraylar less effective.cariprazine (VRAYLAR) Notes: Quantity limits: Yes. ^ Adequate trial is defined as 14 days treatment duration. * Intolerance excludes adverse drug reactions that are expected, mild in nature, resolve with continued treatment, and do not require medication discontinuation. Initiation (new start) criteria: Non-formulary cariprazine (Vraylar) will ...Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. Once verified, the information you provide will be displayed on our site. Actor Name Actor Role -- Role -- Primary Actor Actor Voice Crew Mention Actor Type -- Type -- Actor/Actress Athlete Author Coach Comedian Director Expert Model Musician Public Figure TV ...Other tags: VRAYLAR commercial 2024, cast, girl 2024, actress 2024, song, new, newest

Latuda TV Commercials. We don't make the ads - We measure them. Sign up to track 11 nationally aired TV ad campaigns for Latuda. In the past 30 days, Latuda has had 1,417 airings and earned an airing rank of #733 with a spend ranking of #133 as compared to all other advertisers. Competition for Latuda includes VRAYLAR, REXULTI (Depression ...it's been amazing. I've been on vraylar for 3 months now at 3mg and it's totally controlling my bipolar 1. also no weight gain, I'm actually losing weight for once! 5. Reply. halfdayallday123. • 1 mo. ago. Pretty good. My heart rate went up a little but not to unsafe levels. Seems to blunt the bad emotions pretty good.NORTH CHICAGO, Ill., Feb. 22, 2022 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced that it has submitted a supplemental New Drug Application (sNDA) for cariprazine (VRAYLAR ®) to the U.S ...Hugo Award Nominees 2024. From all the nominations, a final ballot of 6 is. Home / what's on / events. Following a prophecy into death. On february 11, 2024 by laurenjholmes in hugo awards. Nominations Happen From January To March Of 2024. Novel in this context means works over. Direct All Questions About The 2024The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased appetite, and dizziness.

Farmers Insurance lightning strikes a car commercial; Pizza Hut New York Giants NFL debut commercial; ... Who is VRAYLAR Commercial actress 2023 or VRAYLAR Commercial actor 2023 or VRAYLAR Commercial girl 2023 . ... VRAYLAR commercial song name 2023 in people arguing.Eligible patients whose insurer does not cover VRAYLAR (cariprazine) or where coverage restrictions have not been satisfied may pay as little as $75 per 30-day supply for each of up to twelve (12) prescription fills. When insurance covers VRAYLAR (cariprazine), eligible patients may pay as little as $15 for each of up to four (4) 90-day ...Cyrina Fiallo. Actress: Life in Pieces. Cyrina Fiallo is a Cuban-Italian actress and writer, born & raised in Miami, Florida. Since moving to Los Angeles, her more-than-two dozen television appearances include NBC's Brooklyn 99 and Community, Fox's Glee, CW's Supernatural and CBS's Life in Pieces and a recurring role on Disney's Good Luck Charlie. CADTH reanalysis increased the market shares for cariprazine. In the CADTH base case, the anticipated budget impact of reimbursing cariprazine for the treatment of schizophrenia in adults is $1,535,742 in year 1, $5,437,489 in year 2, and $11,695,629 in year 3, for a 3-year total of $18,668,860.

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The effectiveness of Vraylar was established in three, 6-week studies that showed Vraylar was superior to a placebo and, in two studies, equivalent to the active control. The efficacy was established at doses ranging from 1.5mg to 9mg; however, significantly more adverse effects happened at dosages above 6mg, therefore the maximum recommended ...204370. Patent Use Description. TREATMENT OF SCHIZOPHRENIA AND/OR ACUTE MANIC OR MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER WITH CARIPRAZINE. Product Number. 1. Iran Expo. Not Confirmed. Contact Supplier. Patents Listed in the FDA Orange Book Drug Database of VRAYLAR with information and expiry/expiration dates.Some of the commercial's viewers clearly didn't get the memo. One Redditor, u/FamousOhioAppleHorn, offered a strangely specific critique of the new actress. "Jardiance Lady 2 creeps me out," their ...About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features NFL Sunday Ticket …The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased appetite, and dizziness. These are not all the possible side effects of VRAYLAR.Commercial Actresses by motoXTS | created - 05 Mar 2015 | updated ... New Jersey, USA. She is an actress and writer, known for Out of the Box (2020), Your Baby (2015) …

Sep 6, 2023 · Vraylar (cariprazine) is an atypical antipsychotic used to treat schizophrenia and bipolar I disorder in adults. It can also be used as an add-on medication to help with major depressive disorder (MDD). Vraylar (cariprazine) is taken by mouth once a day. Some common side effects of this medication include uncontrolled muscle movements, headache ... The "Carousel" commercial for the bipolar depression medication VRAYLAR.Bailee Madison. Having started her career as a child actor, Bailee Madison has worked with a number of the industry's biggest names — Jennifer Aniston, Natalie Portman, Selena Gomez, Bette ...Get free Vraylar coupons instantly and save up to 80%. See the cheapest pharmacy price and start saving on Vraylar today. Mobile App Providers Blog Help. ... The discount coupons offered by RxSaver are intended for out-of-pocket paying consumers and may not be used with commercial health plans or any federal or state funded health care program ...VRAYLAR ® (cariprazine) is an adjunctive or add-on treatment for major depressive disorder. Eligible commercially insured patients may pay as little as*: $0 for VRAYLAR: both 30- and 90-day fills. $0 for a generic antidepressant. Get your savings card and talk to your doctor about a 90-day prescription to save more time and money at the pharmacy.Vraylar (cariprazine) is an atypical antipsychotic that is manufactured by AbbVie Inc to treat certain mental health conditions. It is approved by the U.S. Food and Drug Administration (FDA) for the: Treatment of schizophrenia in adults. Acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.Bailee Madison. Having started her career as a child actor, Bailee Madison has worked with a number of the industry’s biggest names — Jennifer Aniston, Natalie Portman, Selena Gomez, Bette ...Vraylar is an expensive brand-name medication with no generic alternatives available. The patents for this medication are expected to expire on September 17, 2029, which is the earliest possible date that a generic pharmaceutical company can apply for authorization from the FDA to register the first generic alternative for Vraylar.The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased appetite, and dizziness.Serious side effects of Vraylar that have been reported include: tardive dyskinesia (random movements of your tongue, head, neck, legs, or arms that you can't control) risk of falling due to ...Sep 13, 2021 · Dosage for depressive episodes in bipolar I disorder. If you’re taking Vraylar for depressive episodes of bipolar I disorder, your starting dosage will be 1.5 mg once per day. On day 15 of your ... Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. Once verified, the information you provide will be displayed on our site. Actor Name Actor Role -- Role -- Primary Actor Actor Voice Crew Mention Actor Type -- Type -- Actor/Actress Athlete Author Coach Comedian Director Expert Model Musician Public Figure TV ...

Vraylar is a medication that belongs to a class of drugs called atypical antipsychotics. It contains the active ingredient cariprazine, which works by modulating certain neurotransmitter receptors in the brain, including dopamine and serotonin. By targeting these neurotransmitters, Vraylar helps to restore the balance of chemicals in the brain ...

Depending on your insurance coverage, new eligible commercially insured patients may pay $0 for their first two 30-day fills and as little as $5 for 30- or 90-day refills.* Get your savings card and talk to your doctor about a 90-day prescription to save more time and money at the pharmacy.Published on April 03, 2023. Hotels.com's new series of ads features celebrity voices. Hotels.com’s new ad campaign continues the brand platform developed a year ago with Wieden+Kennedy—but ...high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor; or. severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or ...VRAYLAR: If a strong CYP3A4 inhibitor is initiated, reduce the current dosage of VRAYLAR by half. For patients taking 4.5 mg daily, the dosage should be reduced to 1.5 mg or 3 mg daily. For patients taking 1.5 mg daily, the dosing regimen should be adjusted to every other day. When the CYP3A4 inhibitor isThe actress in the 2023 Opzelura commercial is the American actress Kristen Vaganos. Kristen has been active in the movie industry for years and starred in several movies and TV shows. She's mostly known as Lisa in the 2020 horror movie I Am Lisa: you can find her in the official trailer here. Among other productions, she was the protagonist ...Check out VRAYLAR's 60 second TV commercial, 'You Are Greater: Spirit: $0 For the First 2 Prescriptions' from the Rx: Depression, Bipolar & Insomnia industry. …Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. Once verified, the information you provide will be displayed on our site. Actor Name Actor Role -- Role -- Primary Actor Actor Voice Crew Mention Actor Type -- Type -- Actor/Actress Athlete Author Coach Comedian Director Expert Model Musician Public Figure TV ...Vraylar (cariprazine) is an atypical antipsychotic that treats mental health conditions such as bipolar depression and schizophrenia. It interacts with a number of medications. Carbamazepine (Tegretol), phenytoin (Dilantin), and rifampin (Rifadin) interact with Vraylar by lowering its levels in your body. This can make Vraylar less effective.It is not known if VRAYLAR is safe and effective in children. Do not take VRAYLAR if you are allergic to cariprazine. See the end of this Medication Guide for a complete list of ingredients in VRAYLAR. Before taking VRAYLAR, tell your healthcare provider about all of your medical conditions, including if you: have or have had heart problems or ...Vraylar Actress 2024. Abbvie spent $126.6 million in 2023, massively up from $39.2. Allergan recently announced positive results on three vraylar trials for bipolar depression, and analysts expect the company to file a supplemental drug application this. Abbvie spent $126.6 million in 2023, massively up from $39.2. Vraylar, a sales blockbuster for abbvie that made

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The name of the blonde woman in the blue dress in the Prudential commercial is Courtney Pauroso. She is a commercial actress. Who is the red headed actress in the otezla commercial?Submit ONCE per commercial, and allow 48 to 72 hours for your request to be processed. Once verified, the information you provide will be displayed on our site. Actor Name Actor Role -- Role -- Primary Actor Actor Voice Crew Mention Actor Type -- Type -- Actor/Actress Athlete Author Coach Comedian Director Expert Model Musician Public Figure TV ...Brand name(s) Vraylar. Warning. ... Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Uses. This medication is used to treat certain mental/mood disorders (such as bipolar disorder, depression, schizophrenia). Cariprazine belongs to a class of drugs known as atypical antipsychotics.Vraylar is a medication that belongs to a class of drugs called atypical antipsychotics. It contains the active ingredient cariprazine, which works by modulating certain neurotransmitter receptors in the brain, including dopamine and serotonin. By targeting these neurotransmitters, Vraylar helps to restore the balance of chemicals in the brain ...When she's not working, she loves running around Central Park, making people take #ootd pics of her, and exploring New York City. Celebrity News 2023 Taylor Swift's New Girl Squad Dines in NYCClinical trials show that VRAYLAR is an effective treatment for schizophrenia and bipolar I disorder in adults. Patients taking VRAYLAR have reported improvement in psychotic symptoms, such as hallucinations and delusions, as well as mood symptoms, such as depression and mania. Like all medications, VRAYLAR has potential side effects.Compare prices and print coupons for Vraylar (Cariprazine) and other drugs at CVS, Walgreens, and other pharmacies. Prices start at $1,418.67 ... New and existing commercially insured patients may pay as little as $0 for their 30-day or 90-day fills of VRAYLAR.* ... Vraylar is a brand-name medication2024 Chevy Traverse Weight. Get unbiased reviews and ratings specs for the 2024 chevrolet traverse and compare vehicles with consumer reports. 2024 chevy traverse payload capacity. 2024 chevy traverse payload capacity. Let the overlanding theme of 2023 continue. When Properly Equipped, The New Traverse Has A Max Trailering Rating Of Up To 5,000 Pounds (2,268Cariprazine (Vraylar) is an oral atypical antipsychotic originated by Gedeon Richter. It is a potent dopamine D3 and D2 receptor partial agonist, which preferentially binds to the D3 receptor. ... 0754, New Zealand. [email protected]. PMID: 26510944 DOI: 10.1007/s40265-015-0494-7 Abstract Cariprazine (Vraylar) is an oral atypical antipsychotic ... ….

We would like to show you a description here but the site won't allow us.Nascar Roval 2024. The bank of america roval 400 will be held october 10th, 2021 at the charlotte motor speedway. Chevrolet has now won at least one race in the nascar national ranks every weekend since the roval at charlotte motor speedway last october. How to watch the nascar playoffs at the charlotte roval. MeaningErica Shaffer is an American actress who has worked in independent films and television.. Her film appearances include A Family Affair, The Truth is Always Complicated, The Fall, Catalina Trust, The Socratic Method, Three on a Match and West Coast.. Shaffer's television credits include guest star and recurring roles on Days of Our Lives, Valentine, Eleventh Hour, The Secret Life of the ...Hayden Panettiere is a name that has become synonymous with talent, beauty, and compassion. This multi-talented actress and philanthropist has captivated audiences around the world...Thanks for posting on r/bipolar!. Please take a second to read our rules; if you haven't already, make sure that your post does not have any personal information (including your name/signature/tag on art).. If you are posting about medication, please do not list and review your meds. Doing so will result in the removal of this post and all comments.Clinical trials show that VRAYLAR is an effective treatment for schizophrenia and bipolar I disorder in adults. Patients taking VRAYLAR have reported improvement in psychotic symptoms, such as hallucinations and delusions, as well as mood symptoms, such as depression and mania. Like all medications, VRAYLAR has potential side effects.Last updated on Sep 4, 2023. Official answer. by Drugs.com. Vraylar (cariprazine) may be taken either in the morning or at night, depending on your preference. Cariprazine, the active ingredient of Vraylar, and its metabolites have a long half-life: 2 to 4 days for cariprazine, 1 to 2 days for one active metabolite called DCAR, and ...Voting Rules. Latest additions: Natasha Lyonne, Kerry Washington, Marianne Jean-Baptiste. Most divisive: Lupita Nyong'o. Over 2.5K Ranker voters have come together to rank this list of The Best Actresses Of 2024. Behold the talented women who have graced the screens this year with our list of the best actresses of 2024. New actress in vraylar commercial 2023 name, 19/12/2022. Richter Gedeon's ('Richter') partner AbbVie ('AbbVie') today announced that the U.S. Food and Drug Administration (FDA) has approved VRAYLAR® (cariprazine) as an adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD) in adults. Supported by clinical data demonstrating efficacy and well ..., Cariprazine (CAR) (marketed under the name of Vraylar ®) is a novel antipsychotic, approved in 2015 for the treatment of adults with schizophrenia and manic or mixed episodes associated with ..., VRAYLAR® (cariprazine). 3,378 likes · 30 talking about this. Important Safety Information: https://bit.ly/vraylarISI, Apr 3, 2023 · This program offers Vraylar at no cost to people who qualify. Visit the program site or call 800-222-6885 to learn more. Some websites provide details about drug assistance programs, ways to make ... , By Ben Adams May 9, 2023 9:40am. AbbVie Vraylar depression major depressive disorder. A patient with depression says she was "stuck" until AbbVie's Vraylar gave her "a lift," which is the..., To register for an educational event over the phone, please call 1-888-335-8430. VRAYLAR (cariprazine) is indicated in adults as adjunctive therapy to antidepressants for the treatment of major depressive disorder (MDD), for the treatment of depressive episodes associated with bipolar I disorder (bipolar depression), for the acute treatment of ..., Vraylar (cariprazine) is an atypical antipsychotic.It's FDA approved to treat schizophrenia, bipolar 1 disorder, and hard-to-treat depression.When taking Vraylar, it's helpful to be aware of any precautions you should take. Knowing about possible drug interactions is one precaution that can help keep you safe. Some interactions raise the risk of Vraylar side effects., 16820 posts. re: Vraylar Commercial woman making many sandwiches. Posted on 8/11/18 at 9:50 pm to geaux88. quote: She has that super crazy bitch look in her eyes. Doesn't stop her from making sandwiches. Only that stupid drug does. Imagine how impressed and well fed your baws would be if you had a woman like that., Commercial Actresses by motoXTS | created - 05 Mar 2015 | updated ... New Jersey, USA. She is an actress and writer, known for Out of the Box (2020), Your Baby (2015) …, Other tags: VRAYLAR commercial 2023, cast, girl 2023, actress 2023, song, new, newest, Vraylar is a brand name for a drug called cariprazine, which is used to treat psychological-related disorders such as bipolar depression, bipolar mania, and schizophrenia. Vraylar belongs to the family of second-generation antipsychotics. It balances serotonin and dopamine and acts on the chemicals in the brain, thus improving the thinking ..., • Take VRAYLAR exactly as your healthcare provider tells you to take it. Do not change the dose or stop taking VRAYLAR without first talking to your healthcare provider. • Take VRAYLAR 1 time each day with or without food. • If you take too much VRAYLAR, call your healthcare provider or Poison Control Center at 1-800-222-1222 or, Schizophrenia is characterized by positive, negative, cognitive, and affective symptoms. Antipsychotic medications, which work by blocking the dopamine D 2 receptor, are the foundation of pharmacotherapy for schizophrenia to control positive symptoms. Cariprazine is a dopamine D 3 receptor-preferring D 3 /D 2 partial agonist antipsychotic …, Vraylar. Vraylar comes as a capsule that you take by mouth. Vraylar comes in a 1.5 mg, 3 mg, 4.5 mg and 6 mg capsule strength. It is given once a day, and your doctor can determine the best dose for your treatment plan. Vraylar does not yet have a generic option and may be more expensive than some of the Abilify options., The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, indigestion, constipation, feeling tired, trouble sleeping, increased appetite, and dizziness. These are not all the possible side effects of VRAYLAR. , Dizziness, lightheadedness, drowsiness, nausea, tiredness, excess saliva /drooling, blurred vision, weight gain, or constipation may occur. If any of these effects last or get worse, tell your ... , Brand names: Vraylar. Pregnancy Warnings; Breastfeeding Warnings; Cariprazine Pregnancy Warnings. Use is not recommended. US FDA pregnancy category: Not assigned. Risk Summary: There are no data available to inform of a risk for birth defects or miscarriage. Comments:-A pregnancy exposure registry is available., high blood sugar --increased thirst, increased urination, dry mouth, fruity breath odor; or. severe nervous system reaction --very stiff (rigid) muscles, high fever, sweating, confusion, fast or ..., Aug 23, 2023 · Caffeine is not listed as having a drug interaction with the atypical antipsychotic medicine Vraylar (generic name: cariprazine). However, Vraylar may lead to restlessness, the feeling of the need to move around (akathisia), or trouble with sleeping (insomnia) in some patients. Call a health care provider right away if you or your family member ... , VRAYLAR is a prescribed oral medication that is intended to treat those who have been diagnosed with bipolar depression and acute manic or mixed episodes of bipolar I when taken daily as ordered. Published October 07, 2019 Advertiser VRAYLAR Advertiser Profiles Facebook Products VRAYLAR Promotions $0 co-pay available for qualified patients Tagline, Eligible patients whose insurer does not cover VRAYLAR (cariprazine) or where coverage restrictions have not been satisfied may pay as little as $75 per 30-day supply for each of up to twelve (12) prescription fills. When insurance covers VRAYLAR (cariprazine), eligible patients may pay as little as $15 for each of up to four (4) 90-day ..., "We are pleased with the FDA approval of VRAYLAR, which represents an important new treatment option for adults living with bipolar I disorder and schizophrenia to help address the unmet medical ..., VRAYLAR TV Commercial, 'Unstoppable' He added, "Mania is the misunderstood end of the bipolar spectrum. Depression is understood by most people, whether directly or through a friend of loved one., VRAYLAR ® (cariprazine) is an adjunctive or add-on treatment for major depressive disorder. Eligible commercially insured patients may pay as little as*: $0 for VRAYLAR: both 30- and 90-day fills. $0 for a generic antidepressant. Get your savings card and talk to your doctor about a 90-day prescription to save more time and money at the pharmacy., 'The Company You Keep' is a new drama series starring Milo Ventimiglia. The show premieres February 19 on ABC. The official synopsis reads: 'A night of passion leads to love between con man ..., The list of march 2024 new music releases includes new albums from judas priest and iron maiden frontman bruce dickinson, as well as a key reissue from alice cooper. Source: www.youtube.com. Best Mashups & Remixes Of Popular Songs 2023 Party Dance Mix 2023, Explore list of new remixes of old songs 2023. Top 50 songs and house music / edm bangers., Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when VRAYLAR or the antidepressant is started or when the dose is changed. Report any change in these symptoms immediately to the doctor., New and existing commercially insured patients may pay as little as $0 for their 30-day or 90-day fills of VRAYLAR.* *See our Terms and Conditions to see if you qualify. Check Your Eligibility, Vraylar is a prescription bipolar disorder treatment medication also used to treat schizophrenia and bipolar depression. Buy Vraylar online at a lower price. ... When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount. You'll have option to make 4 interest-free ..., Cyrina Fiallo. Actress: Life in Pieces. Cyrina Fiallo is a Cuban-Italian actress and writer, born & raised in Miami, Florida. Since moving to Los Angeles, her more-than-two dozen television appearances include NBC's Brooklyn 99 and Community, Fox's Glee, CW's Supernatural and CBS's Life in Pieces and a recurring role on Disney's Good Luck Charlie., Whether you’re a talent scout for a commercial production company or just a curious TV viewer, you might’ve wondered about the actors who bring some of TV’s most recognizable chara..., Flu-like symptoms that might occur following Vraylar cessation include: muscle aches or weakness; headaches; nausea; vomiting; body temperature changes; and sweating. It may be helpful to use over-the-counter medications (e.g. anti-inflammatories) to attenuate flu-like symptoms throughout withdrawal., Vraylar: Cariprazine belongs to the class of medications called antipsychotics. It is used to treat schizophrenia and bipolar disorder. It does not cure these medical conditions, but helps to manage symptoms by affecting the actions of certain chemical messengers in the brain.